As the industry leader in epigenetics, Zymo Research offers a complete collection of kits, products and individual components for epigenetics research.

Bisulfite Conversion Kits


Streamlined, simplified, and proven procedures for bisulfite conversion of DNA. Recommended by Illumina’s Golden Gate and Infinium Assays.

Pico Methyl-Seq Library Prep Kit

D5455, D5456

All-inclusive kit for bisulfite conversion followed by Whole Genome Bisulfite Sequencing (WGBS) library preparation.

Zymo-Seq RRBS Library Kit

D5460, D5461

The Zymo-Seq RRBS Library Kit is an all-inclusive library prep kit for low-input library preparation of Reduced Representation of Bisulfite Sequencing (RRBS) to profile genome-wide DNA methylation.

Zymo-Seq RiboFree Total RNA Kit

R3000, R3003

The fastest and easiest kit for stranded total RNA-seq libraries with RiboFree Universal Depletion for any sample and species

Zymo-Seq RiboFree Universal cDNA Kit


This universal rRNA and globin depletion kit is probe-free and produces RiboFree single-stranded cDNA with minimal hands-on time.

Human Methylated & Non-methylated DNA Set

D5014, D5014-1, D5014-2

Methylated and non-methylated DNA controls with primer sets to assess bisulfite conversion efficiency and for DNA methylation quantification.


D5325, D5326

Global 5-mC detection and quantitation.

OneStep qMethyl-PCR Kit

D5310, D5311

A bisulfite-free DNA methylation analysis; Rapid screening of single/multiple loci

Quest 5-hmC DNA ELISA Kit

D5425, D5426

Global 5-hmC detection and quantitation.

RRHP 5-hmC Library Prep Kit

D5450, D5451

Innovative 5-hmC library preparation kit for strand-specific mapping of 5-hmC in DNA.

ZymoTaq Polymerase


ZymoTaq DNA Polymerase contains all the reagents needed to perform “hot-start” PCR. This unique product is specifically designed for the amplification of bisulfite-treated DNA for methylation detection, but is applicable for conventional PCR.

Zymo-Spin ChIP Kit

D5209, D5210

The Zymo-Spin ChIP Kit is a ChIP kit that provides a streamlined ChIP procedure for investigating protein-DNA interactions.


Epigenetics is the study of modifications to an organism’s genome that affect the regulation of the genes rather than changes to the actual genetic code. Epigenetic modifications can result in changes to the structure of chromatin which then affects which genes be expressed as proteins within the cell. These modifications are stable and heritable as classical genetic mechanisms. Their regulation is complicated and a topic of interest for many studies, especially those concerned with gene expression, development, and cellular differentiation.

Epigenetics is regulated by DNA methylation, DNA hydroxymethylation, and non-coding RNAs. To study these modifications, Zymo Research has a variety of epigenetic research products designed to simplify workflows and provide reliable results. This suite of epigenetic research products is of the highest quality and most cited technologies. With these epigenetic products, Zymo Research is dedicated to improving studies by enabling scientists with the tools necessary to elucidate genetic regulation, cellular differentiation, embryology, aging, cancer, and any other field.