Click Chemistry Auxiliary Reagents
- THPTA
- BTTAA
- BTTES
- BTTP
- TBTA
Copper-chelating ligands that improve efficiency and biocompatibility of CuAAC.
THPTA (tris-hydroxypropyltriazolylmethylamine) is a water-soluble, very effective accelerating ligand for copper-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA minimizes perturbations to the physiological state of the cells or organisms probed and allows for the effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation. The water-soluble THPTA ligand further simplifies click chemistry by allowing the entire reaction to be run in water.
THPTA (CCT-1010)
BTTAA is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.
BTTAA (CCT-1236)
BTTES is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation.
BTTES (CCT-1237)
BTTP is a newest generation, accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.
BTTP (CCT-1414)
TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF.