NF-kB is a transcription factor that plays a critical role in regulating the immune response, inflammation, cell survival, and proliferation. The NF-kB signaling pathway is a complex intracellular signaling cascade involved in modulating gene expression in response to various stimuli, such as cytokines, pathogens, and oxidative stress.
Activation of the NF-kB pathway involves the phosphorylation and degradation of inhibitory molecules, leading to the translocation of NF-kB into the nucleus where it binds to specific DNA sequences and regulates the expression of target genes. This results in the production of pro-inflammatory cytokines, chemokines, and anti-apoptotic proteins that play a crucial role in the immune response.
Dysregulation of the NF-kB pathway has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Therefore, understanding the mechanisms that control NF-kB signaling is essential for developing targeted therapies to modulate this pathway for therapeutic purposes. Researchers continue to investigate the intricate details of NF-kB signaling to uncover new insights into its role in health and disease.
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