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GPCR/G protein

GPCRs (G-protein coupled receptors) are a major subcategory of signaling pathways that play a crucial role in transmitting signals from outside the cell to within. These receptors are involved in a wide range of physiological processes including sensory perception, neurotransmission, hormonal regulation, and immune responses.

When a ligand binds to a GPCR, it causes a conformational change in the receptor that activates an associated G-protein. The activated G-protein then triggers a cascade of intracellular signaling events that ultimately lead to a specific cellular response.

GPCRs are a diverse family of proteins that can be classified into different subtypes based on their structure and function. Some examples of GPCR subtypes include rhodopsin-like, secretin-like, and metabotropic glutamate receptors.

Dysregulation of GPCR signaling pathways has been implicated in a variety of diseases, including cancer, cardiovascular disorders, and neurological conditions. Therefore, understanding the mechanisms underlying GPCR/G protein signaling is essential for the development of novel therapeutics targeted at these pathways.

Product Search

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MBX-2982, A3587, C22H24N8OS, GPR119 agonist,selective and orally-available
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LY341495, A3577, C20H19NO5, Metabotropic glutamate receptor antagonist
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LY341495, A3577, C20H19NO5, Metabotropic glutamate receptor antagonist
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LUF6000, A3563, C22H20Cl2N4, A3 AR modulator
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LUF6000, A3563, C22H20Cl2N4, A3 AR modulator
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Lu AE58054 Hydrochloride, A3561, C20H20ClF5N2O, 5-HT(6)R antagonist
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Lu AE58054 Hydrochloride, A3561, C20H20ClF5N2O, 5-HT(6)R antagonist
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Laropiprant, A3538, C21H19ClFNO4S, DP1 receptor antagonist,potent and selective
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Laropiprant, A3538, C21H19ClFNO4S, DP1 receptor antagonist,potent and selective
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INCB8761(PF-4136309), A3495, C29H31F3N6O3, CCR2 Antagonist,potent and selective

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