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Apoptosis

Apoptosis is a crucial subcategory of signaling pathways that plays a vital role in regulating cell death. This process is essential for maintaining tissue homeostasis, eliminating unwanted or damaged cells, and preventing the proliferation of abnormal cells that could lead to diseases like cancer.

Apoptosis is a highly orchestrated and controlled mechanism that involves a series of molecular signals and pathways. These signaling pathways can be triggered by a variety of internal and external stimuli, such as DNA damage, oxidative stress, or hormonal signals. The activation of these pathways ultimately leads to the activation of a cascade of proteins that culminates in the orderly dismantling of the cell.

Dysregulation of apoptosis can have serious consequences and is associated with a wide range of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Understanding the mechanisms of apoptosis and its signaling pathways is crucial for developing targeted therapies to modulate cell death and promote cell survival in various disease states.

Overall, apoptosis is a fundamental process in biology that plays a critical role in maintaining tissue integrity and cellular homeostasis. It is a complex and highly regulated process that is essential for normal development and tissue maintenance.

Product Search

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2-HBA, C3234, C17H14O3, indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
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CBL0137 (hydrochloride), C3192, C21H24N2O2·HCl, curaxin that activates p53 and inhibits NF-κB
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CBL0137, C3171, C21H24N2O2, curaxin that activates p53 and inhibits NF-κB
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R-7050, C3129, C16H8ClF3N4S, TNF-α receptor signaling antagonist,cell-permeable
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AD57 (hydrochloride), C3080, C22H20F3N7O·HCl, polypharmacological cancer therapeutic that inhibits RET.
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ML-354, C3058, C16H14N2O3, PAR4 antagonist
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U 73343, B9013, C29H42N2O3, A negative control of the putative phospholipase C inhibitor U 73122
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RHC 80267, B9005, C20H34N4O4, diacylglycerol lipase inhibitor
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Selonsertib (GS-4997), B7812, C24H24FN7O, apoptosis signal-regulating kinase 1 (ASK1) inhibitor
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UC 112, B7790, C22H24N2O2, IAP inhibitor

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