• Select from >2 500 unique synthetic and natural-based scaffolds
• Specify MW limits of screening compounds
• Define any other inclusion/exclusion parameters
• Be supplied with up to 200 – 500 compounds per scaffold
• Choose to have compounds supplied exclusively or non-exclusively
• Define timeframe of the project

With a network of nearly 3,000 chemists in well-equipped labs across East Europe and Central Asia states, Interbioscreen has the resources, expertise and infrastructure to synthesize screening compounds from the scaffolds of your choice. Scaffold approach is not combinatorial chemistry. This is a custom synthesis project, which means that if you select any number of scaffolds from the database, the chemist will synthesize from 100- 500 derivatives of that structure. Syntheses can be very different, some involving to 12 steps. The most value of this project is in that the synthesis is performed in accordance with the customer’s guidelines /filters. Each company has its own objectives and thus specific requirements to the compounds they would wish to obtain. Since the selection of scaffolds is customer’s, this means that the customer is the first to receive custom-made compounds of their choice.

The classification of the Building Blocks is indicated in the following fields.

• PA  Primary Amines
• SA  Secondary Amines
• AL  Alcohols
• AK  Aldehydes & Ketones
• CA  Carboxylic Acids
• ES  Esters
• AN  Anhydrides & Haloanhydrides
• PH  Phenols
• AA  Aminoacids & their derivatives
• PE  Peptides & their derivatives
• CH  Carbohydrates & their derivatives
• NU  Nucleotides & Nucleosides
• ST  Steroids & Terpenoids
• HAE  Haloid Alkyles & Epoxydes
• SH  Thiols
• OCC  Other Chemical Classes or Polyfunctional reagents
• HY  Hydrazines & Hydrazones
• IC  Isocyanates
• ITC  Isothiocyanates
• SC  Sulfochlorides

BIO database currently contains 789 compounds. In addition to the chemical and physical properties, each compound is accompanied by data on its biological use, mechanism of action, biological source (where applicable) and literature references.

IBS started to build up the NC collection in 1984, and to-date it has grown to include over 68000 compounds. Originally the main contributors of natural compounds & derivatives were research institutes of the former Soviet Union, e.g. institutes for plant chemistry, bioorganic chemistry, botanical institutes, institutes for biochemistry of microorganisms, phytopathology of plants etc. With time, we have expanded our sources of rare and unique natural compounds and over the past decade the collection has considerably grown due to the influx of natural products from Asia, Latin America, some European centers for natural products etc. In percentage terms, the collection can be said to comprise 30 – 35% of strictly natural compounds isolated from plants, microorganisms, marine species etc.; approximately 40% are derivatives of natural compounds, i.e. modified alkaloids, terpenoids, flavonoids etc, and the remaining 25-30% are mimetics (analogs) of the strictly natural compounds, e.g. azosteroids, azocoumarins, conjugated isoindole systems, oxaterpenoids etc.

Of the whole NC library, 60 – 65% are compounds of plant origin; 5-10% were isolated from microorganisms, about 5% from marine species and the rest from other natural sources. All compounds have purity at 92-98%. The structures and stereochemistry are confirmed by various physicochemical analytical methods, including NMR (Brucker 300 – 500 MHz), mass spectroscopy and in some cases X-ray analysis.

The most representative classes include various types of alkaloids (several thousand compounds), terpenoids (several thousand), flavonoids and coumarins (over 3 000 compounds), peptides, glycosides and nucleosides (over 1 000 compounds), phenol compounds (several hundred). The collection is also rich in rare and unusual compounds, such as various classes of phytoalexins, allelopathic agents, specific sex attractants, natural toxins, unusual sesquiterpenoids and other secondary metabolites. Apart from this, we also have a collection of functionalized natural compounds which can be used in Natural Combinatorial Chemistry as natural matrices. Compounds in this collection are available in the amounts from several grams up to several hundred grams. As a rule, we package natural compounds in vials or microplates as 2 mg – 5 mg – 10 mg – 20 mg – 50 mg samples.

Part of the integrated IBS SC collection is composed of the best of the Syntest Ltd., NELBI Ltd., ChemEx Inc., ExiMed Ltd. collections. Interbioscreen has purchased these selected sub-collections which are now Interbioscreen’s property. The synthetic library of IBS is built around functionalized heterocyclic drug-like molecules. Most of these cannot be obtained combinatorially. From the very start, IBS has been generating its library by making a very strict selection of the most interesting classes of compounds which have potential of becoming new drugs or plant protection agents or preparations for use in veterinary. We were less interested in simple hydrazones, hydrazides, Schiff’s bases or readily decomposing compounds. The major criterion for the inclusion of a compound in the collection has been the novelty, abundance in pharmacophores, diversity and the “drug-like molecule” structure.