Human Neutrophil Gelatinase-associated Lipocalin, NGAL ELISA Kit
Product Summary
• Size: 48T,96T
• Sensitivity: 2.01ng/ml
• Detection range: 5-600ng/ml
• Reactive with: Human
Product Details
Product Specifications |
|
---|---|
Full Product Name: |
Neutrophil Gelatinase-Associated Lipocalin |
Catalog No.: |
BL1719EH |
Size: |
48T,96T |
Detaction Range: |
5-600ng/ml |
Sensitivity: |
2.01ng/ml |
Sample Type: |
Serum, plasma, cell culture supernates |
Assay Type: |
Sandwich |
Species: |
Human |
Storage: |
2-8ºC |
Assay Time: |
1h 30m |
Background: |
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed: 12453413, PubMed: 27780864, PubMed: 20581821). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed: 27780864). Can also bind siderophores from M.tuberculosis (PubMed: 15642259, PubMed: 21978368). |
UniProt: |
|
MASS(Da): |
22,588 |
GeneID: |
3934 |
Synonyms: |
25 kDa alpha-2-microglobulin-related subunit of MMP-9;LCN 2;LCN2;Lipocalin-2;Neutrophil gelatinase-associated lipocalin;NGAL;Oncogene 24p3;p25;Siderocalin; |
Gene Names: |
LCN2 |
Research Area: |
Metabolism |
Target Protein: |
LCN2 |
*For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Components
Components | Quantity |
Pre-coated ELISA Plate | 12 * 8 well strips x1 |
Standard solution | 0.5ml x1 |
Standard diluent | 3ml x1 |
Streptavidin-HRP | 6ml x1 |
Stop solution | 6ml x1 |
Substrate solution A | 6ml x1 |
Substrate solution B | 6ml x1 |
Wash buffer concentrate | (25x) 20ml x1 |
Biotinylated antibody | 1ml x1 |
Documents
Technical Guide
Technical Guide: Human Neutrophil Gelatinase-associated Lipocalin, NGAL ELISA KitSafety Data Sheets (SDS)
MSDS: Human Neutrophil Gelatinase-associated Lipocalin, NGAL ELISA KitReferences
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