Human Nesprin-2, SYNE2 ELISA Kit
Product Summary
• Size: 48T,96T
• Sensitivity: 7.68ng/L
• Detection range: 15-3000ng/L
• Reactive with: Human
Product Details
Product Specifications |
|
---|---|
Full Product Name: |
Nesprin-2 |
Catalog No.: |
BL5748EH |
Size: |
48T,96T |
Detaction Range: |
15-3000ng/L |
Sensitivity: |
7.68ng/L |
Sample Type: |
Serum, plasma, cell culture supernates |
Assay Type: |
Sandwich |
Species: |
Human |
Storage: |
2-8ºC |
Assay Time: |
1h 30m |
Background: |
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. |
UniProt: |
|
MASS(Da): |
796,442 |
GeneID: |
23224 |
Synonyms: |
KASH domain-containing protein 2;KASH2;Nesprin-2;Nuclear envelope spectrin repeat protein 2;Nucleus and actin connecting element protein;Protein NUANCE;Synaptic nuclear envelope protein 2;SYNE 2;SYNE2;Syne-2 |
Gene Names: |
SYNE2 |
Research Area: |
Tags & Cell Markers |
Target Protein: |
SYNE2 |
*For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Components
Components | Quantity |
Pre-coated ELISA Plate | 12 * 8 well strips x1 |
Standard solution | 0.5ml x1 |
Standard diluent | 3ml x1 |
Streptavidin-HRP | 6ml x1 |
Stop solution | 6ml x1 |
Substrate solution A | 6ml x1 |
Substrate solution B | 6ml x1 |
Wash buffer concentrate | (25x) 20ml x1 |
Biotinylated antibody | 1ml x1 |
Documents
Technical Guide
Technical Guide: Human Nesprin-2, SYNE2 ELISA KitSafety Data Sheets (SDS)
MSDS: Human Nesprin-2, SYNE2 ELISA KitReferences
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