Human Mucolipin 1, MCOLN1 ELISA Kit
Product Summary
• Size: 48T,96T
• Sensitivity: 0.024ng/ml
• Detection range: 0.05-30ng/ml
• Reactive with: Human
Product Details
Product Specifications |
|
---|---|
Full Product Name: |
Mucolipin 1 |
Catalog No.: |
BL2917EH |
Size: |
48T,96T |
Detaction Range: |
0.05-30ng/ml |
Sensitivity: |
0.024ng/ml |
Sample Type: |
Serum, plasma, cell culture supernates |
Assay Type: |
Sandwich |
Species: |
Human |
Storage: |
2-8ºC |
Assay Time: |
1h 30m |
Background: |
Nonselective cation Channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed: 11013137, PubMed: 12459486, PubMed: 15336987, PubMed: 14749347, PubMed: 29019983, PubMed: 27623384). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed: 16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed: 27787197, PubMed: 25733853). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed: 27357649). Functions as a Fe(2+) permeable Channel in late endosomes and lysosomes (PubMed: 18794901). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed: 25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. |
UniProt: |
|
MASS(Da): |
65,022 |
GeneID: |
57192 |
Synonyms: |
MCOLN 1;MCOLN1;MG-2;ML1;Mucolipidin;Mucolipin-1;Transient receptor potential Channel mucolipin 1;TRPML1 |
Gene Names: |
MCOLN1 |
Research Area: |
Signal Transduction |
Target Protein: |
MCOLN1 |
*For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Components
Components | Quantity |
Pre-coated ELISA Plate | 12 * 8 well strips x1 |
Standard solution | 0.5ml x1 |
Standard diluent | 3ml x1 |
Streptavidin-HRP | 6ml x1 |
Stop solution | 6ml x1 |
Substrate solution A | 6ml x1 |
Substrate solution B | 6ml x1 |
Wash buffer concentrate | (25x) 20ml x1 |
Biotinylated antibody | 1ml x1 |
Documents
Technical Guide
Technical Guide: Human Mucolipin 1, MCOLN1 ELISA KitSafety Data Sheets (SDS)
MSDS: Human Mucolipin 1, MCOLN1 ELISA KitReferences
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