Full Product Name:

Hypoxia-Inducible Factor 1-Alpha Inhibitor

Catalog No.:

BL3080EH

Size:

48T,96T

Detaction Range:

10-2000ng/L

Sensitivity:

5.09ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Human

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

UniProt:

Q9NWT6

MASS（Da）:

40,285

GeneID:

55662

Synonyms:

Factor inhibiting HIF-1;FIH-1;HIF1AN;Hypoxia-inducible factor 1-alpha inhibitor;Hypoxia-inducible factor asparagine hydroxylase

Gene Names:

HIF1AN

Research Area:

Others

Target Protein:

HIF1AN