Human Fibroblast Growth Factor Receptor 1, FGFR1 ELISA Kit
Product Summary
• Size: 48T,96T
• Sensitivity: 0.027ng/ml
• Detection range: 0.05-30ng/ml
• Reactive with: Human
Product Details
Product Specifications |
|
---|---|
Full Product Name: |
Fibroblast Growth Factor Receptor 1 |
Catalog No.: |
BL3588EH |
Size: |
48T,96T |
Detaction Range: |
0.05-30ng/ml |
Sensitivity: |
0.027ng/ml |
Sample Type: |
Serum, plasma, cell culture supernates |
Assay Type: |
Sandwich |
Species: |
Human |
Storage: |
2-8ºC |
Assay Time: |
1h 30m |
Background: |
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
UniProt: |
|
MASS(Da): |
91,868 |
GeneID: |
2260 |
Synonyms: |
Basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;CD antigen CD331;FGFR 1;FGFR1;FGFR-1;Fibroblast growth factor receptor 1;FLT-2;Fms-like tyrosine kinase 2;N-sam;Proto-oncogene c-Fgr |
Gene Names: |
FGFR1 |
Research Area: |
Others |
Target Protein: |
FGFR1 |
*For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Components
Components | Quantity |
Pre-coated ELISA Plate | 12 * 8 well strips x1 |
Standard solution | 0.5ml x1 |
Standard diluent | 3ml x1 |
Streptavidin-HRP | 6ml x1 |
Stop solution | 6ml x1 |
Substrate solution A | 6ml x1 |
Substrate solution B | 6ml x1 |
Wash buffer concentrate | (25x) 20ml x1 |
Biotinylated antibody | 1ml x1 |
Documents
Technical Guide
Technical Guide: Human Fibroblast Growth Factor Receptor 1, FGFR1 ELISA KitSafety Data Sheets (SDS)
MSDS: Human Fibroblast Growth Factor Receptor 1, FGFR1 ELISA KitReferences
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