Full Product Name:

Complement Component 5

Catalog No.:

BL0347EH

Size:

48T,96T

Detaction Range:

0.05-10mg/ml

Sensitivity:

0.021mg/ml

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Human

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed: 8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

UniProt:

P01031

MASS（Da）:

188,305

GeneID:

727

Synonyms:

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4;C5;C5a anaphylatoxin;Complement C5;Complement C5 alpha chain;Complement C5 alpha' chain;Complement C5 beta chain

Gene Names:

C5

Research Area:

Others

Target Protein:

C5