Human Caspase Recruitment Domain-containing Protein 9, CARD9 ELISA Kit
Product Summary
• Size: 48T,96T
• Sensitivity: 5.03ng/L
• Detection range: 10-2000ng/L
• Reactive with: Human
Product Details
Product Specifications |
|
---|---|
Full Product Name: |
Caspase Recruitment Domain-Containing Protein 9 |
Catalog No.: |
BL4992EH |
Size: |
48T,96T |
Detaction Range: |
10-2000ng/L |
Sensitivity: |
5.03ng/L |
Sample Type: |
Serum, plasma, cell culture supernates |
Assay Type: |
Sandwich |
Species: |
Human |
Storage: |
2-8ºC |
Assay Time: |
1h 30m |
Background: |
Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells. |
UniProt: |
|
MASS(Da): |
62,241 |
GeneID: |
64170 |
Synonyms: |
CARD 9;CARD9;Caspase recruitment domain-containing protein 9;hCARD9 |
Gene Names: |
CARD9 |
Research Area: |
Others |
Target Protein: |
CARD9 |
*For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Components
Components | Quantity |
Pre-coated ELISA Plate | 12 * 8 well strips x1 |
Standard solution | 0.5ml x1 |
Standard diluent | 3ml x1 |
Streptavidin-HRP | 6ml x1 |
Stop solution | 6ml x1 |
Substrate solution A | 6ml x1 |
Substrate solution B | 6ml x1 |
Wash buffer concentrate | (25x) 20ml x1 |
Biotinylated antibody | 1ml x1 |
Documents
Technical Guide
Technical Guide: Human Caspase Recruitment Domain-containing Protein 9, CARD9 ELISA KitSafety Data Sheets (SDS)
MSDS: Human Caspase Recruitment Domain-containing Protein 9, CARD9 ELISA KitReferences
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