Full Product Name:

Caspase-6

Catalog No.:

BL4993EH

Size:

48T,96T

Detaction Range:

15-3000ng/L

Sensitivity:

7.79ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Human

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed: 8663580, PubMed: 32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed: 17401638, PubMed: 8663580, PubMed: 9463409). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed: 10559921, PubMed: 14657026). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed: 32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed: 32298652).

UniProt:

P55212

MASS（Da）:

33,310

GeneID:

839

Synonyms:

Apoptotic protease Mch-2;CASP 6;CASP6;CASP-6;Caspase-6;Caspase-6 subunit p11;Caspase-6 subunit p18

Gene Names:

CASP6

Research Area:

Neuroscience; Cell Biology; Cancer; Metabolism

Target Protein:

CASP6