Full Product Name:

Alpha-2-Macroglobulin-Like Protein 1

Catalog No.:

BL4926EH

Size:

48T,96T

Detaction Range:

5-1000ng/mL

Sensitivity:

2.29ng/mL

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Human

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a Peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

UniProt:

A8K2U0

MASS（Da）:

161,107

GeneID:

144568

Synonyms:

A2ML1;Alpha-2-macroglobulin-like protein 1;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9

Gene Names:

A2ML1

Research Area:

Others

Target Protein:

A2ML1