Full Product Name:

Thioredoxin reductase 1

Catalog No.:

BL2252E

Size:

48T,96T

Detaction Range:

0.1-40mU/mL

Sensitivity:

0.057mU/mL

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

UniProt:

O62768

MASS（Da）:

54,770

GeneID:

282388

Synonyms:

Thioredoxin reductase 1, cytoplasmic;Thioredoxin reductase TR1;TR;TXNRD1

Gene Names:

TXNRD1

Research Area:

Signal Transduction

Target Protein:

TXNRD1