Full Product Name:

Protein Disulfide-Isomerase

Catalog No.:

BL2246E

Size:

48T,96T

Detaction Range:

0.5-200ng/mL

Sensitivity:

0.32ng/mL

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

UniProt:

P05307

MASS（Da）:

57,266

GeneID:

281373

Synonyms:

Cellular thyroid hormone-binding protein;P4HB;p55;PDI;Prolyl 4-hydroxylase subunit beta;Protein disulfide-isomerase

Gene Names:

P4HB

Research Area:

Others

Target Protein:

P4HB