Full Product Name:

Myeloid Differentiation Primary Response Protein Myd88

Catalog No.:

BL2236E

Size:

48T,96T

Detaction Range:

15-3000ng/L

Sensitivity:

8.12ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed: 17936907, PubMed: 18760477). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).

UniProt:

Q599T9

MASS（Da）:

33,709

GeneID:

444881

Synonyms:

MYD 88;MYD88;Myeloid differentiation primary response protein MyD88

Gene Names:

MYD88

Research Area:

Signal Transduction

Target Protein:

MYD88