Full Product Name:

Major Prion Protein

Catalog No.:

BL2230E

Size:

48T,96T

Detaction Range:

0.05-20ng/ml

Sensitivity:

0.021ng/ml

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

UniProt:

P10279

MASS（Da）:

28,614

GeneID:

281427

Synonyms:

CD antigen CD230;Major prion protein;Major scrapie-associated fibril protein 1;PRNP;PrP

Gene Names:

PRNP

Research Area:

Neuroscience

Target Protein:

PRNP