Full Product Name:

Interleukin-12 Subunit Beta

Catalog No.:

BL2225E

Size:

48T,96T

Detaction Range:

10-2000ng/L

Sensitivity:

5.31ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).

UniProt:

P46282

MASS（Da）:

37,050

GeneID:

281857

Synonyms:

CLMF p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL 12B;IL 12beta;IL-12 subunit p40;IL12B;IL-12B;Interleukin-12 subunit beta

Gene Names:

IL12B

Research Area:

Immunology

Target Protein:

IL12B