Full Product Name:

Deoxyribonuclease 1

Catalog No.:

BL0173E

Size:

48T,96T

Detaction Range:

7-1500ng/L

Sensitivity:

3.91ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed: 4976790, PubMed: 5166750, PubMed: 3352748, PubMed: 2395459). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed: 2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed: 2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).

UniProt:

P00639

MASS（Da）:

31,346

GeneID:

282217

Synonyms:

Deoxyribonuclease I;Deoxyribonuclease-1;DNASE 1;DNase I;DNASE1

Gene Names:

DNASE1

Research Area:

Epigenetics and Nuclear Signaling

Target Protein:

DNASE1