Full Product Name:

C-X-C Motif Chemokine 10

Catalog No.:

BL2202E

Size:

48T,96T

Detaction Range:

30-9000ng/L

Sensitivity:

12.56ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).

UniProt:

Q2KIQ8

MASS（Da）:

11,427

GeneID:

615107

Synonyms:

C-X-C motif chemokine 10;CXCL 10;CXCL10;Small-inducible cytokine B10

Gene Names:

CXCL10

Research Area:

Immunology; Microbiology; Cancer

Target Protein:

CXCL10