Bovine C-C Motif Chemokine 20, CCL20 ELISA Kit
Product Summary
• Size: 48T,96T
• Sensitivity: 5.09ng/L
• Detection range: 10-2000ng/L
• Reactive with: Bovine
Product Details
Product Specifications |
|
---|---|
Full Product Name: |
C-C Motif Chemokine 20 |
Catalog No.: |
BL2195E |
Size: |
48T,96T |
Detaction Range: |
10-2000ng/L |
Sensitivity: |
5.09ng/L |
Sample Type: |
Serum, plasma, cell culture supernates |
Assay Type: |
Sandwich |
Species: |
Bovine |
Storage: |
2-8ºC |
Assay Time: |
1h 30m |
Background: |
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. |
UniProt: |
|
MASS(Da): |
10,964 |
GeneID: |
281666 |
Synonyms: |
C-C motif chemokine 20;CCL 20;CCL20;Macrophage inflammatory protein 3 alpha;MIP-3-alpha;Small-inducible cytokine A20 |
Gene Names: |
CCL20 |
Research Area: |
Immunology; Signal Transduction |
Target Protein: |
CCL20 |
*For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Components
Components | Quantity |
Pre-coated ELISA Plate | 12 * 8 well strips x1 |
Standard solution | 0.5ml x1 |
Standard diluent | 3ml x1 |
Streptavidin-HRP | 6ml x1 |
Stop solution | 6ml x1 |
Substrate solution A | 6ml x1 |
Substrate solution B | 6ml x1 |
Wash buffer concentrate | (25x) 20ml x1 |
Biotinylated antibody | 1ml x1 |
Documents
Technical Guide
Technical Guide: Bovine C-C Motif Chemokine 20, CCL20 ELISA KitSafety Data Sheets (SDS)
MSDS: Bovine C-C Motif Chemokine 20, CCL20 ELISA KitReferences
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