Full Product Name:

72 kDa type IV collagenase

Catalog No.:

BL2183E

Size:

48T,96T

Detaction Range:

10-2000ng/ml

Sensitivity:

5.19ng/ml

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).

UniProt:

Q9GLE5

MASS（Da）:

73,777

GeneID:

282872

Synonyms:

72 kDa gelatinase;72 kDa type IV collagenase;Matrix Metalloproteinase-2;MMP 2;MMP2;MMP-2

Gene Names:

MMP2

Research Area:

Others

Target Protein:

MMP2