Ryanodine Receptor Polyclonal Antibody
- Size: 100ul
- Application: ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC)
- Reactivity: Mouse, Rat
- Predicted Reactivity: Human, Dog, Cow, Pig, Rabbit
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Datasheet
Tech Support
IMAGES
Formalin-fixed and paraffin embedded rat heart labeled with Anti-Ryanodine Receptor Polyclonal Antibody, Unconjugated (bs-6305R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
Ryanodine Receptor Polyclonal Antibody |
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CONJUGATION |
Unconjugated |
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HOST |
Rabbit |
| SOURCE |
KLH conjugated synthetic peptide derived from human Ryanodine Receptor |
| IMMUNOGEN RANGE |
4701-4800/5038 |
| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at -20°C for 12 months.. |
TARGET |
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| GENE ID |
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| SUBCELLULAR LOCATION |
Cytoplasm, Cell membrane |
| SYNONYMS |
Arrhythmogenic right ventricular dysplasia 2; ARVC 2; ARVC2; ARVD 2; ARVD2; Brain ryanodine receptor calcium release channel; Brain type ryanodine receptor; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor calcium release channel; Cardiac muscle type ryanodine receptor; CCO; Central core disease of muscle; HBRR; hRYR 2; hRYR2; MHS; MHS1; Ryanodine receptor 1 skeletal; Ryanodine receptor 1; Ryanodine receptor 2 cardiac; Ryanodine receptor 2; Ryanodine receptor 3; Ryanodine receptor type1; RYDR; RYR 1; RYR 2; RYR 3; RYR; RYR1; RYR2; RYR3; Sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle type ryanodine receptor; SKRR; Type 1 like ryanodine receptor; VTSIP. |
| BACKGROUND |
The Ryanodine Receptor (RyR) is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum (SR) and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule and the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle and areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain; and RyR-3 is found in smooth muscle and the brain (striatum, thalamus and hippocampus). In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta and cardiac which correlate loosely to the mammalian RyR-1, RyR-3 and RyR-2 isoforms respectively. |
| APPLICATION DILUTION |
ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200) |