presenilin 1 Polyclonal Antibody
- Size: 100ul
- Application: ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC)
- Reactivity: Mouse
- Predicted Reactivity: Human, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
presenilin 1 Polyclonal Antibody |
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CONJUGATION |
Unconjugated |
|
HOST |
Mouse |
| SOURCE |
KLH conjugated synthetic peptide derived from rat presenilin 1 |
| IMMUNOGEN RANGE |
10-80/467 |
| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at -20°C for 12 months.. |
TARGET |
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| GENE ID |
|
| SUBCELLULAR LOCATION |
Cytoplasm |
| SYNONYMS |
Presenilin-1; PS-1; Protein S182; Psen1; Psnl1 |
| BACKGROUND |
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity). |
| APPLICATION DILUTION |
ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200) |