p107(Ser975) Polyclonal Antibody


p107(Ser975) Polyclonal Antibody

  • Size: 100ul
  • Application: WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC)
  • Reactivity: Human, Mouse, Rat
  • Predicted Reactivity: Dog, Cow, Sheep, Pig, Horse

  • Datasheet      Tech Support


Catalog# bs-5696R

Size:100ul Datasheet


 SizePrice
 100ul ₹ 33990

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

p107(Ser975) Polyclonal Antibody

CONJUGATION

Unconjugated

HOST

Rabbit

SOURCE

KLH conjugated synthetic phosphopeptide derived from human RBL1 around the phosphorylation site of Ser975

IMMUNOGEN RANGE

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at -20°C for 12 months..


TARGET

GENE ID

5933

SUBCELLULAR LOCATION

Nucleus

SYNONYMS

PRB1; p107; CP107; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; RBL1

BACKGROUND

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

APPLICATION DILUTION

WB(1:300-1000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)












CITATION






  • Wang et al. SirtuinÊ1Êpromotes the proliferation of C2C12Êmyoblast cells via the myostatin signaling pathway. (2016) Mol.Med.Rep. 14:1309-15, Mol.Med.Rep.
    WB | Rat


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