PRODUCT NAME

LGI1 Monoclonal Antibody

CONJUGATION

Unconjugated

HOST

Rabbit

SOURCE

Recombinant protein corresponding to Human LGI1.

IMMUNOGEN RANGE

CLONALITY

Monoclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at -20°C for 12 months..

GENE ID

9211

SUBCELLULAR LOCATION

Secreted, Synapse

SYNONYMS

ADLTE antibody, ADPAEF antibody, ADPEAF antibody, Epitempin 1 antibody, EPITEMPIN antibody, Epitempin-1 antibody, EPT antibody, ETL1 antibody, IB1099 antibody, leucine rich glioma inactivated 1 antibody, Leucine rich glioma-inactivated protein 1 antibody, Leucine-rich glioma-inactivated protein 1 antibody, LGI1 antibody, LGI1_HUMAN antibody, OTTHUMP00000020121 antibody, OTTHUMP00000020122 antibody

BACKGROUND

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. Tissue specificity;Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level).

APPLICATION DILUTION

WB(1:300-1000)