PRODUCT NAME

Estrogen Receptor alpha Monoclonal Antibody

CONJUGATION

Unconjugated

HOST

Rabbit

SOURCE

Synthetic Peptide within N-terminal Human Estrogen Receptor alpha.

IMMUNOGEN RANGE

CLONALITY

Monoclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at -20°C for 12 months..

GENE ID

2099

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Cell membrane

SYNONYMS

7*/654 isoform antibody, 7*/819 2 isoform antibody, 7*/822 isoform antibody, 8*/901 isoform antibody, 8*/941 isoform antibody, DKFZp686N23123 antibody, ER alpha antibody, ER antibody, ER-alpha antibody, Era antibody, ESR antibody, ESR1 antibody, ESR1_HUMAN antibody, ESRA antibody, Estradiol receptor antibody, Estrogen nuclear receptor alpha antibody, Estrogen receptor 1 antibody, Estrogen receptor alpha 3*,4,5,6,7*/822 isoform antibody, Estrogen receptor alpha antibody, Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform antibody, Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform antibody, Estrogen receptor alpha delta 4 +49 isoform antibody, Estrogen receptor alpha delta 4*,5,6,7*/654 isoform antibody, Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform antibody, Estrogen receptor alpha E1 E2 1 2 antibody, Estrogen receptor alpha E1 N2 E2 1 2 antibody, Estrogen receptor antibody, ESTRR antibody, NR3A1 antibody, Nuclear receptor subfamily 3 group A member 1 antibody

BACKGROUND

The estrogen receptor (ER) is a 66 kDa protein that mediates the actions of estrogens in estrogen responsive tissues. It is a member of a large superfamily of nuclear hormone receptors that function as ligand activated transcription factors. The ER gene consists of more than 140 kb of genomic DNA divided into 8 exons. These translate into a protein with six functionally discrete domains, labeled A through F. A second form of the estrogen receptor, ER beta has recently been described. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti estrogen (e.g. tamoxifen) therapy.

APPLICATION DILUTION

WB(1:300-1000)