DOK1 (Tyr398) Polyclonal Antibody, HRP Conjugated
- Size: 100ul
- Application: WB, ELISA, IHC-P, IHC-F
- Reactivity: Mouse
- Predicted Reactivity: Human, Rat, Dog, Cow, Pig, Horse
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
DOK1 (Tyr398) Polyclonal Antibody, HRP Conjugated |
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CONJUGATION |
HRP |
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HOST |
Rabbit |
| SOURCE |
KLH conjugated synthetic phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr398 |
| IMMUNOGEN RANGE |
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| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. |
| STORAGE CONDITION |
Store at 4°C for 12 months. |
TARGET |
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| GENE ID |
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| SUBCELLULAR LOCATION |
Cytoplasm |
| SYNONYMS |
DOK1 phospho Y398; DOK1 phospho Tyr398; p-DOK1 phospho Y398; docking protein 1 downstream of tyrosine kinase 1; Docking protein 1 p62dok Downstream of tyrosine kinase 1 pp62.; docking protein 1 62kD downstream of tyrosine kinase 1; Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62dok; P62DOK; pp62; pp62. |
| BACKGROUND |
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
| APPLICATION DILUTION |
WB(1:300-1000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500) |