Beta catenin Monoclonal Antibody, Biotin Conjugated
- Size: 100ul
- Application: WB
- Reactivity: Human, Mouse, Rat
- Predicted Reactivity:
-
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
Beta catenin Monoclonal Antibody, Biotin Conjugated |
CONJUGATION |
Biotin |
HOST |
Mouse |
SOURCE |
Recombinant human Beta catenin |
IMMUNOGEN RANGE |
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CLONALITY |
Monoclonal |
ISOTYPE |
IgG |
CONCENTRATION |
1ug/ul |
PURIFICATION |
Purified by Protein G. |
STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
STORAGE CONDITION |
Store at -20°C for 12 months. |
TARGET |
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GENE ID |
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SUBCELLULAR LOCATION |
Cytoplasm, Cytomembrane |
SYNONYMS |
beta-catenin; beta catenin; CTNNB1; CHBCAT; CTNNB1; CTNNB; PRO2286; Cadherin associated protein; Catenin (cadherin associated protein), beta 1, 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CTNB1_HUMAN; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; b-catenin; .OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289;Catenin-_; Catenin _. |
BACKGROUND |
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. |
APPLICATION DILUTION |
WB(1:300-1000) |