PRODUCT NAME

Adalimumab Biosimilar - Research Grade

SPECIES REACTIVITY

Human

HOST

Humanized

SPECIFICITY

Detects human TNF alpha. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Adalimumab. This product is for research use only.

PURIFICATION METHOD

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

ANTIGEN DISTRIBUTION

Activated monocytes, neutrophils, macrophages, T cells, B cells, NK cells, LAK cells

IMMUNOGEN

CONCENTRATION

FORMULATION

Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.

PURITY

>95% by SDS-PAGE and HPLC

ENDOTOXIN

≤ 0.75 EU/mg as determined by the LAL method

AGGRIGATION

STORAGE CONDITION

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

TARGET

TNF alpha

CLONE

SYNONYMS

BACKGROUND

Adalimumab biosimilar is a recombinant human IgG1 monoclonal antibody specific for human tumor necrosis factor (TNF)，was created using phage display technology resulting in an antibody with human derived heavy and light chain variable regions and human IgG1:k constant regions. Adalimumab biosimilar is produced by recombinant DNA technology in a mammalian cell (Chinese Hamster Ovary) expression system and is purified by a process that includes specific viral inactivation and removal steps. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons.

UNIPROT

PATHOGEN TEST

APPLICATIONS

APPLICATION NOTES

USAGE

Products are for research use only. Not for use in diagnostic or therapeutic procedures.