Anti-Mouse TNF alpha In Vivo Antibody – Ultra Low Endotoxin (TN3-19.12 )

Anti-Mouse TNF alpha In Vivo Antibody – Ultra Low Endotoxin (TN3-19.12 )


Anti-Mouse TNF alpha In Vivo Antibody – Ultra Low Endotoxin (TN3-19.12 )

  • Sizes: 5mg, 25mg, 50mg, 100mg,
  • Category: ichorbio, Ultra Low Endotoxin, anti-mouse
  • Target: TNF alpha
  • Clone: TN3-19.12
  • Host: Armenian Hamster

  • Datasheet      Tech Support


Catalog# ICH1136UL

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

Anti-Mouse TNF alpha In Vivo Antibody - Ultra Low Endotoxin (TN3-19.12 )

SPECIES REACTIVITY

Mouse

HOST

Armenian Hamster

SPECIFICITY

Anti-TNF alpha In Vivo Antibody - Ultra Low Endotoxin (TN3-19.12 ) recognizes Mouse TNFa

PURIFICATION METHOD

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

ANTIGEN DISTRIBUTION

Activated monocytes, neutrophils, macrophages, T cells, B cells, NK cells, LAK cells

IMMUNOGEN

Recombinant mouse TNFalpha

CONCENTRATION

FORMULATION

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.

PURITY

>98% by SDS-PAGE and HPLC

ENDOTOXIN

≤ 0.75 EU/mg as determined by the LAL method

AGGRIGATION

Aggregation level ≤ 1%

STORAGE CONDITION

anti-TNF alpha In Vivo Antibody - Ultra Low Endotoxin (TN3-19.12 ) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.


TARGET

TARGET

TNF alpha

CLONE

TN3-19.12

SYNONYMS

BACKGROUND

The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha

UNIPROT

P06804

PATHOGEN TEST

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our hamster antibodies are tested for:
Mycoplasma spp
Mycoplasma pulmonis
Pneumonia virus of mice
Kilham's rat virus
Toolan's H1 virus
Hamster parvovirus
Lymphocytic choriomeningitis
Minute virus of mice
Theiler's murine encephalomyelitis virus
Sendai virus
Reovirus 3
Hantaan virus

APPLICATIONS

Immunoprecipitation, Western Blot, Functional Assays, Flow Cytometry, Blocking

APPLICATION NOTES

Each investigator should determine their own optimal working dilution for specific applications.

USAGE

Products are for research use only. Not for use in diagnostic or therapeutic procedures.












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