Bulk anti-Human CD119 antibody (GIR 208)
- Sizes: 5mg, 25mg, 50mg, 100mg,
- Category: ichorbio, Ultra Low Endotoxin, anti-human
- Target: CD119
- Clone: GIR 208
- Host: Mouse
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
Bulk anti-Human CD119 antibody (GIR 208) |
SPECIES REACTIVITY |
Human |
HOST |
Mouse |
SPECIFICITY |
Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) recognizes Human IFN gamma R alpha |
PURIFICATION METHOD |
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. |
ANTIGEN DISTRIBUTION |
The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes. |
IMMUNOGEN |
Human IFN-gamma R alpha, Purified from human placenta |
CONCENTRATION |
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FORMULATION |
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. |
PURITY |
>98% by SDS-PAGE and HPLC |
ENDOTOXIN |
≤ 0.75 EU/mg as determined by the LAL method |
AGGRIGATION |
Aggregation level ≤ 1% |
STORAGE CONDITION |
anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) is stable when stored at 2-8°C. For long term storage we recommended to store at -80°C. |
TARGET |
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TARGET |
CD119 |
CLONE |
GIR 208 |
SYNONYMS |
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BACKGROUND |
Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor. |
UNIPROT |
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PATHOGEN TEST |
We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: |
APPLICATIONS |
Immunoprecipitation, Western Blot, Blocking, Functional Assays |
APPLICATION NOTES |
Functional Assay: Clone GIR-208 can be used as an isotype with Clone MAR1-5A3 (Anti-Mouse IFNAR1) |
USAGE |
Products are for research use only. Not for use in diagnostic or therapeutic procedures. |