eIF3B Monoclonal Antibody
- Size: 100ul
- Application: WB, FCM, IHC-P, IF(ICC)
- Reactivity: Human, Mouse, Rat
- Predicted Reactivity:
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
eIF3B Monoclonal Antibody |
CONJUGATION |
Unconjugated |
HOST |
Rabbit |
SOURCE |
Synthetic Peptide within N terminal human eIF3B. |
IMMUNOGEN RANGE |
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CLONALITY |
Monoclonal |
ISOTYPE |
IgG |
CONCENTRATION |
1ug/ul |
PURIFICATION |
Purified by Protein A. |
STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
STORAGE CONDITION |
Store at -20°C for 12 months.. |
TARGET |
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GENE ID |
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SUBCELLULAR LOCATION |
Cytoplasm |
SYNONYMS |
eIF-3-eta antibody, eIF3 eta antibody, eIF3 p110 antibody, eIF3 p116 antibody, EIF3-ETA antibody, EIF3-P110 antibody, EIF3-P116 antibody, eIF3b antibody, EIF3B_HUMAN antibody, EIF3S9 antibody, EIF3S9, formerly antibody, Eukaryotic translation initiation factor 3, subunit B antibody, Eukaryotic translation initiation factor 3 subunit 9 antibody, eukaryotic translation initiation factor 3 subunit 9 eta antibody, Eukaryotic translation initiation factor 3 subunit B antibody, eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD) antibody, eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa antibody, eukaryotic translation initiation factor 3, subunit 9, formerly antibody, hPrt1 antibody, Protein synthesis defective at 36 degrees celsius 1, S. cerevisiae, homolog of antibody, PRT1 antibody, Prt1 homolog antibody |
BACKGROUND |
eIF3b expression relates to human bladder and prostate cancer prognosis, is required for tumor growth, and thus a candidate therapeutic target.The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis. |
APPLICATION DILUTION |
WB(1:300-1000), FCM(1:20-100), IHC-P(1:200-400), IF(ICC)(1:50-200) |