Ado-trastuzumab emtansine Biosimilar – Research Grade
- Sizes: 0.1mg, 5mg, 20mg, ,
- Category: ichorbio, Low endotoxin, biosimilar antibody, ADC
- Target: HER2
- Clone:
- Host: Humanized
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
Ado-trastuzumab emtansine Biosimilar - Research Grade |
SPECIES REACTIVITY |
Human |
HOST |
Humanized |
SPECIFICITY |
Detects human HER2. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ado-trastuzumab emtansine. This product is for research use only. |
PURIFICATION METHOD |
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. |
ANTIGEN DISTRIBUTION |
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IMMUNOGEN |
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CONCENTRATION |
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FORMULATION |
Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free. |
PURITY |
>95% by SDS-PAGE and HPLC |
ENDOTOXIN |
≤ 0.75 EU/mg as determined by the LAL method |
AGGRIGATION |
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STORAGE CONDITION |
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles. |
TARGET |
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TARGET |
HER2 |
CLONE |
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SYNONYMS |
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BACKGROUND |
Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody. |
UNIPROT |
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PATHOGEN TEST |
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APPLICATIONS |
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APPLICATION NOTES |
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USAGE |
Products are for research use only. Not for use in diagnostic or therapeutic procedures. |