Description
Lithocholic acid (LCA) is a hydrophobic secondary bile acid that is primarily formed in the intestine by the bacterial 7-α dehydroxylation of chenodeoxycholic acid. Acts as a detergent to solubilize fats for absorption. Known to display both carcinogenic and apoptotic activities. Also binds to the p53 binding sites of both MDM2 and MDM4 with a five-fold preference for MDM4.
Datasheet
| Cat # +Size | 2187-1G (Size: 1 g ) 2187-5G (Size: 5g ) |
|---|---|
| Alternate Name | 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol; LCA |
| Appearance | White to off-white solid |
| CAS # | 434-13-9 |
| Molecular Formula | C₂₄H₄₀O₃ |
| Molecular Weight | 376.57 |
| Purity | ≥97% by TLC |
| Solubility | DMSO or EtOH |
| SMILES | CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C |
| InChi | InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1 |
| InChi Key | SMEROWZSTRWXGI-HVATVPOCSA-N |
| PubChem CID | 9903 |
| MDL Number | MFCD00003682 |
| Handling | Protect from air and moisture |
| Storage Conditions | RT |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
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