sTLR4 acts as a potent inhibitor ofTLR4-mediated inflammation, blocking the interaction between TLR4 and other coreceptor complexes, especiallyMD2 and CD14, …
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear re…
Sphingosine 1‐phosphate (SPP) is an important sphingolipid‐derived second messenger in mammalian cells that acts to promote proliferation and to inhibit apop…
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stim…
Phospholipase C releases diacylglycerol by cleaving the glycosylphosphatidylinositol. It has broad substrate specificity and its activity is influenced by me…
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit…
