Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-hi…
Forms a water-specific Channel (PubMed: 8660998, PubMed: 9276712, PubMed: 18286643). Plays an important role in brain water homeostasis and in glymphatic sol…
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation i…
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target c…
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimul…
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9…
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 t…
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed: 7503239). In macrophages, NO mediates tumoricida…
