Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play e…
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed: 9524238). Does not show metalloendopeptidase activity …
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to …
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis.…
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety…
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the gr…
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicati…
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyos…
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phospho…
