Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate syn…
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activ…
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, follow…
An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic P…
An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic P…
Binds Peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition …
Plays a central role in cell adhesion in hematopoietic cells (PubMed: 19234463, PubMed: 26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and…
Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine Peptides, including neurotensin, angiotensin I, substanc…
Aminopeptidase that plays a central role in Peptide trimming, a step required for the generation of most HLA class I-binding Peptides. Peptide trimming is es…
