Epigenetics and Nuclear Signaling

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiati…

Required for both DNA replication and mitosis (PubMed: 11125146, PubMed: 22581055, PubMed: 21856198, PubMed: 14993212, PubMed: 26842564). DNA replication lic…

May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed: 11809763). Plays a role in the brain as a key controller

Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave…

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and …

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.…

Plays a role in lysosome motility (PubMed: 16537643, PubMed: 25898167). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysos…

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-acti…

Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed: 15322075, PubMed: 15775988, PubMed: 19672300). Plays an essential…

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the ante…