Involved in the Notch signaling pathway as Notch ligand (PubMed: 11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endot…
Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterni…
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell g…
Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair…
The Insulin-like growth factors possess growth-promoting activity (PubMed: 29440408). Major fetal growth hormone in mammals. Plays a key role in regulating f…
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinoph…
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed: 29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6),
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries…
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion ma…
