Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell g…
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions i…
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, …
Plays a major role in tight junction-specific obliteration of the intercellular space. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) e…
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed: 11799113, PubMed: 1629222, PubMed…
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play e…
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed: 9524238). Does not show metalloendopeptidase activity …
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to …
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis.…
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety…
