Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:
Endogenous ligand for the apelin receptor (APLNR) (PubMed: 10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates mo…
Plays a central role in autophagy (PubMed: 23184933, PubMed: 28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinosi…
Receptor tyrosine kinase which mediates actions of Insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower…
Inward rectifier potassium Channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed: 3024962, PubMed: 3900070, PubMed: 3593230,…
Calcium Channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle cont…
Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHR…
Induces cartilage and bone formation (PubMed: 3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP…
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Ac…
