Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed: 29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6),
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral mi…
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endot…
Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium Channel KCNH2/HERG, or by assisting its synthesis, foldin…
Exhibits a potent RNase activity (PubMed: 12244054, PubMed: 12527768, PubMed: 17150966). Has broad-spectrum antimicrobial activity against many pathogenic mi…
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule…
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts …
