Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Rat Anti-diuretic hormone, ADH ELISA Kit, E0385Ra
Hormone secreted by the posterior pituitary gland (trade name Pitressin) and also by nerve endings in the hypothalamus; affects blood pressure by stimulating capillary muscles and reduces urine flow by affecting reabsorption of water by kidney tubules.
Human A disintegrin and metalloproteinase with thrombospondin motifs 9, ADAMTS9 ELISA Kit, E3558Hu
Cleaves the large aggregating proteoglycans, aggrecan (at the ‘1838-Glu-|-Ala-1839’ site) and versican (at the ‘1428-Glu-|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
Human 8-Hydroxy-desoxyguanosine, 8-OHdG ELISA Kit, E1436Hu
8-hydroxy-2′-deoxyguanosine (8-OHdG) ELISA Kit is used for quantitative measurement of 8-OHdG in serum, plasma, tissue homogenates, culture supernatants and other biological fluids.
Rat 5-Hydroxytryptamine Receptor 7, 5-HTR7 ELISA Kit, E3324Ra
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This receptor is implicated in the regulation of mammalian circadian rhythms.
Rat Serotonin, 5-HT ELISA Kit, E0866Ra
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine found in the central nervous system, gastrointestinal tract, and blood with broad physiological functions as a neurotransmitter, in gastric motility, hemostasis, and cardiovascular integrity. Defects in serotonin signaling have been linked to a large number of complex behavioral disorders in humans, including anxiety and depression, autism, and eating disorders, and to neurodegenerative disorders such as Parkinson’s. Platelets serve as the major reservoir of serotonin in the bloodstream. When activated, platelets release serotonin into the bloodstream where it acts as a powerful vasoconstrictor. Treatment with Selective Serotonin Uptake Inhibitors (SSRIs) dramatically reduces platelet serotonin concentrations, and altered levels of serotonin in the circulatory system are implicated in such diverse conditions such as asthma, liver cirrhosis and carcinoid tumors.
Human 4-Hydroxynonenal, 4HNE ELISA Kit, E1978Hu
4-hydroxynonenal (4-HNE) is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4- HNE is widely used as a marker of lipid peroxidation. It is also in higher quantities during oxidative stress due to the increase in the lipid peroxidation chain reaction. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. It also inhibits Sirtuin 3 (SIRT3) via thiol-specific modification.
Human 3-Nitrotyrosine, 3-NT ELISA Kit, E1425Hu
3-NT is a post-translational modification in proteins occurring through the action of a nitrating agent resulting in the addition of aNO2 group leading to protein tyrosine nitration.
Human 25-hydroxyvitamin D3, 25(OH)D3 ELISA Kit, E1981Hu
a metabolically activated form of cholecalciferol (vitamin D3) synthesized in the liver.
Rat 17 beta Estradiol, 17B-E2 ELISA Kit, E1393Ra
17β-Estradiol is a greatly under-appreciated neural growth and trophic factor for the mammalian brain of all ages.