Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed: 17167421). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed: 15123599). (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed: 15123599). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed: 15123599).
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