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Background
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Product overview
Product Name
Dedicator of Cytokinesis Protein 1
Code
E1998Mo
Assay type
Sandwich
Size
96 test
Sensitivity
14.13ng/L
Reactivity
Mouse
Detection range
14.13ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
180 kDa protein downstream of CRK;Dedicator of cytokinesis protein 1;DOCK 1;DOCK1;DOCK180
