Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed: 16461343, PubMed: 18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating ‘Tyr-394’ residue (PubMed: 21719704). Dephosphorylates ZAP70 at its activating ‘Tyr-493’ residue (PubMed: 16461343). Dephosphorylates the immune system activator SKAP2 (PubMed: 21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed: 23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed: 23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).
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